Our Kidneys Filter Around 140 to 150 Liters of Fluid Daily, but Only One to Two Liters Are Excreted into the Bladder. The rest is returned to the body through the bloodstream. As we age, kidney scarring and tissue hardening can impair their ability to filter our blood, allowing proteins to leak into our urine. This pathological process is known as glomerulosclerosis. Treatment for this age-related kidney dysfunction includes dialysis or kidney transplantation.
NMN enhances the activation of the longevity enzyme Sirtuin-1, which in turn reduces enzymes associated with kidney tissue damage. These findings provide evidence that NMN helps restore the cells necessary for waste filtration in kidney disease (podocytes).
Taking 500 mg/Day of Pure NMN Reduces Kidney Damage
In scientific reports, Wakino and colleagues from Tokushima University in Japan discovered that injecting 500 mg/day of pure NMN reduces kidney damage in mice with a model of focal segmental glomerulosclerosis, a disease with a similar pathology to age-related glomerulosclerosis.
NMN restores the number of podocytes, the essential cells for kidney waste filtration. Moreover, it strengthens fundamental molecules for cellular health, specifically nicotinamide adenine dinucleotide (NAD+), which plays a crucial role in cell regeneration and kidney protection.
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The albumin-to-creatinine ratio (ACR), an indicator of excess protein in urine, dramatically increases in mice with adriamycin (ADR)-induced glomerulosclerosis compared to normal mice (Cont), but NMN (NMN500) improves this effect. Additionally, the number of podocytes decreases in ADR mice, but NMN restores their count.
NMN Influences Protein Levels in Urine
Since higher protein levels in urine are associated with kidney damage and impaired filtration, Wakino and colleagues examined how NMN affects urinary protein levels. The research team simulated glomerulosclerosis by injecting the chemotherapy drug (adriamycin), which causes kidney damage in mice.
Mice modeling kidney disease had significantly elevated protein levels in their urine. However, treatment with NMN reduced urinary protein levels, suggesting reduced kidney damage and improved protein filtration.
What is NMN?
NMN is a low-molecular-weight molecule that is easily absorbed by all cells, where it is converted into NAD+. NAD+ is present in all our cells and supports the regeneration of red blood cells, which can be deformed due to various deficiencies.
Additionally, NMN acts as a powerful oxidative agent and energy source in the body. Our body naturally produces its own NAD+, but as we age, its levels decline. Studies suggest that NMN supplementation may potentially help mitigate muscle aging (sarcopenia).
It would be a mistake to think that the key to healthy longevity lies solely in cold exposure, fasting, or lifelong abstinence. A crucial role is also played by diet, dietary supplements, and scientifically proven anti-aging medications. As we age, our body naturally stops producing NAD+, and its deficiency accelerates aging, leading to cell degeneration.
Example of Healthy Oxidized Cells Under a Darkfield Microscope
More information about this method can be found on our website in the ABOU US section.
Benefits of NMN Supplementation from Anjolie
"We decided to produce NMN for two main reasons. First and foremost, we value its beneficial effects, which we have tested on ourselves for a long time. We believe in its effectiveness and know that it works. The second reason was the price. Our own production, compared to other manufacturers, makes NMN accessible to a wider audience, which brings us great satisfaction."
Our capsules contain one gram of pure NMN per day at a very affordable price.