For the first time, scientists have demonstrated that a daily dose of 1500 mg of NMN can be safely consumed over an extended period. Studies on rodents have shown that nicotinamide mononucleotide (NMN) supplementation alleviates various age-related diseases, including neurological, cardiovascular, and metabolic disorders.
Additionally, clinical studies suggest that NMN supplementation may have positive effects in humans, such as improving muscle mobility in older men and enhancing insulin sensitivity in postmenopausal women. However, it was still necessary to determine the maximum safe doses beyond which NMN could become toxic.
A study published in Food and Chemical Toxicology, led by Canault and colleagues from LGD Biotech in France, demonstrates that rats can safely consume up to 1500 mg of NMN per day for 90 days. Throughout this period, no adverse physical or neurobehavioral effects were observed, suggesting that doses equal to or higher than this amount may also be safe for humans.
Daily NMN Dosages for Humans
These findings indicate that doses of up to 1000 mg per day for an adult weighing approximately 60 kg—which is equivalent to 1500 mg/day in rats - can be safely consumed without adverse physical effects.
Adults who take more than 1000 mg of NMN daily should consider consulting a doctor, especially regarding potential negative effects on the liver or kidneys when using higher doses for an extended period. Further research is needed to determine whether high NMN doses may have harmful side effects on these organs.